Journal
NATURE CHEMICAL BIOLOGY
Volume 5, Issue 11, Pages 797-807Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.251
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Funding
- US National Science Foundation
- PhRMA Foundation Predoctoral Fellowship
- Direct For Biological Sciences [0744541] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [0744541] Funding Source: National Science Foundation
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Predictive methods for the computational design of proteins search for amino acid sequences adopting desired structures that perform specific functions. Typically, design of 'function' is formulated as engineering new and altered binding activities into proteins. Progress in the design of functional protein-protein interactions is directed toward engineering proteins to precisely control biological processes by specifically recognizing desired interaction partners while avoiding competitors. The field is aiming for strategies to harness recent advances in high-resolution computational modeling-particularly those exploiting protein conformational variability-to engineer new functions and incorporate many functional requirements simultaneously.
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