Journal
NATURE CHEMICAL BIOLOGY
Volume 5, Issue 2, Pages 91-93Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.134
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Funding
- Australian Research Council (ARC)
- National Health and Medical Research Council of Australia (NHMRC)
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We used NMR spectroscopy, molecular modeling and infectivity competition assays to investigate the key interactions between the spike protein (VP8*) from 'sialidase-insensitive' human Wa and 'sialidase-sensitive' porcine CRW-8 rotaviruses and the glycans of gangliosides G(M1) and G(D1a). Our data provide strong evidence that N-acetylneuraminic acid is a key determinant for binding of these rotaviruses. This is in contrast to the widely accepted paradigm that sialic acids are irrelevant in host cell recognition by sialidase-insensitive rotaviruses.
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