Journal
NATURE CHEMICAL BIOLOGY
Volume 4, Issue 3, Pages 194-196Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.67
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Funding
- NIDDK NIH HHS [DK45776] Funding Source: Medline
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The reactivity and relative rarity of most cofactors pose challenges for their delivery to target enzymes. Using kinetic analyses, we demonstrate that adenosyltransferase, which catalyzes the final step in the assimilation of coenzyme B-12, directly transfers the cofactor to methylmalonyl coenzyme A mutase. The strategy of using the final enzyme in an assimilation pathway for tailoring a cofactor and delivering it to a dependent enzyme may be general for cofactor trafficking.
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