Journal
NATURE CHEMICAL BIOLOGY
Volume 4, Issue 7, Pages 405-407Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio.91
Keywords
-
Categories
Funding
- NCI NIH HHS [CA087660, R01 CA087660-08, R01 CA087660, R37 CA087660] Funding Source: Medline
Ask authors/readers for more resources
Insights into the proteome reactivity of electrophiles are crucial for designing activity-based probes for enzymes lacking cognate affinity labels. Here, we show that different classes of carbon electrophiles exhibit markedly distinct amino acid labeling profiles in proteomes, ranging from selective reactivity with cysteine to adducts with several amino acids. These data specify electrophilic chemotypes with restricted and permissive reactivity profiles to guide the design of next-generation functional proteomics probes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available