Journal
NATURE CHEMICAL BIOLOGY
Volume 4, Issue 3, Pages 145-147Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio0308-145
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Funding
- NICHD NIH HHS [HD39522] Funding Source: Medline
- NIDDK NIH HHS [R01 DK044464, DK61763, R37 DK044464, DK44464, R01 DK044464-13, R01 DK061763-09, DK074192, R01 DK074192, R01 DK061763] Funding Source: Medline
- NIEHS NIH HHS [P42 ES010356, 5P42ES010356] Funding Source: Medline
- NIGMS NIH HHS [GM41840, R01 GM041840] Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R37DK044464, R01DK044464, R01DK061763, R01DK074192] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P42ES010356] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM041840] Funding Source: NIH RePORTER
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Transition metals function as cofactors in specific proteins, catalyzing electron exchange reactions, binding substrates and stabilizing protein structure. Studies of human diseases and of model organisms have defined many of the molecular details of metal uptake, trafficking, and excretion. The current challenge is to integrate these details into a systematic view of metal content, speciation, localization and use within organisms and ecosystems.
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