Journal
NATURE CHEMICAL BIOLOGY
Volume 4, Issue 1, Pages 15-16Publisher
NATURE RESEARCH
DOI: 10.1038/nchembio0108-15
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Analysis of the multifunctional bone morphogenetic protein (BMP) signaling pathway has been hampered by the lack of specific reagents for discriminating downstream signaling events. A new study uses a novel zebrafish embryo screen to identify dorsomorphin, the first small-molecule inhibitor of BMP signaling, and shows its application in fields as diverse as osteogenesis, developmental patterning and iron homeostasis.
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