Journal
NATURE CHEMICAL BIOLOGY
Volume 4, Issue 8, Pages 448-449Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio0808-448
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Phosphorylation and glycosylation of the tau protein, which is implicated in neurodegenerative diseases, are intimately linked. In vivo pharmacological inhibition of tau deglycosylation may be a new way to suppress abnormal tau phosphorylation, known to be involved in the formation of neurofibrillary tangles in the brain.
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