Journal
NATURE CHEMICAL BIOLOGY
Volume 4, Issue 11, Pages 643-647Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nchembio1108-643
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Although much is known about the molecular components of cellular signaling pathways, very little is known about how these multicomponent biochemical machineries process complex extracellular signals to generate a consolidated cellular response. A newly developed theoretical approach for reverse engineering network structure analyzing how perturbations propagate in a network-can be combined with chemical perturbations and quantitative detection approaches to reveal the causal connections within protein networks in cells. This information indicates the dynamic capabilities of a network and thereby its potential function.
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