Journal
NATURE CELL BIOLOGY
Volume 20, Issue 10, Pages 1110-1117Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/s41556-018-0201-5
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Funding
- NIGMS NIH HHS [R01 GM079431] Funding Source: Medline
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Autophagy influences cell survival through maintenance of cell bioenergetics and clearance of protein aggregates and damaged organelles. Several lines of evidence indicate that autophagy is a multifaceted regulator of cell death, but controversy exists over whether autophagy alone can drive cell death under physiologically relevant circumstances. Here, we review the role of autophagy in cell death and examine how autophagy interfaces with other forms of cell death including apoptosis and necrosis.
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