Journal
NATURE CELL BIOLOGY
Volume 16, Issue 8, Pages 717-727Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3015
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Funding
- American Cancer Society Scholar
- AACR Gertrude B. Elion Cancer Research Scholar
- Presidential Early Career Award for Scientists and Engineers scholar
- National Institutes of Health (NCI) [RO1 CA166284]
- American Cancer Society
- Breast Cancer Research Foundation (BCRF)
- National Institutes of Health (NIH) [R01 CA078461, P01 CA080111]
- Ludwig Center for Molecular Oncology at MIT
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Recent pre-clinical and clinical research has provided evidence that cancer progression is driven not only by a tumour's underlying genetic alterations and paracrine interactions within the tumour microenvironment, but also by complex systemic processes. We review these emerging paradigms of cancer pathophysiology and discuss how a clearer understanding of systemic regulation of cancer progression could guide development of new therapeutic modalities and efforts to prevent disease relapse following initial diagnosis and treatment.
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