Journal
NATURE CELL BIOLOGY
Volume 16, Issue 11, Pages 1035-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb3052
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Funding
- ANR (smORFpeptides and Chrononet)
- Association pour la Recherche sur le Cancer [12011669]
- Azm & Saade Association
- JST PRESTO program
- MEXT KAKENHI [21115007]
- Fondation RITC
- Grants-in-Aid for Scientific Research [21115007, 25114002, 26113006] Funding Source: KAKEN
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Animal development fundamentally relies on the precise control, in space and time, of genome expression. Whereas we have a wealth of information about spatial patterning, the mechanisms underlying temporal control remain poorly understood. Here we show that Pri peptides, encoded by small open reading frames, are direct mediators of the steroid hormone ecdysone for the timing of developmental programs in Drosophila. We identify a previously uncharacterized enzyme of ecdysone biosynthesis, GstE14, and find that ecdysone triggers pri expression to define the onset of epidermal trichome development, through post-translational control of the Shavenbaby transcription factor. We show that manipulating pri expression is sufficient to either put on hold or induce premature differentiation of trichomes. Furthermore, we find that ecdysone-dependent regulation of pri is not restricted to epidermis and occurs over various tissues and times. Together, these findings provide a molecular framework to explain how systemic hormonal control coordinates specific programs of differentiation with developmental timing.
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