Journal
NATURE CELL BIOLOGY
Volume 16, Issue 1, Pages 2-9Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2897
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Funding
- National Institutes of Health
- NATIONAL CANCER INSTITUTE [T32CA009302] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES016486] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM100489] Funding Source: NIH RePORTER
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Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.
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