Journal
NATURE CELL BIOLOGY
Volume 16, Issue 3, Pages 217-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2917
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Funding
- C'nano Ile de France
- Association Christelle Bouillot
- Association pour la Recherche sur le Cancer
- Labex CelTisPhyBio
- Institut Curie Programme Incitatif et Cooperatif 'Physique de la Cellule'
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The leading front of a collectively migrating epithelium often destabilizes into multicellular migration fingers where a cell initially similar to the others becomes a leader cell while its neighbours do not alter. The determinants of these leader cells include mechanical and biochemical cues, often under the control of small GTPases. However, an accurate dynamic cartography of both mechanical and biochemical activities remains to be established. Here, by mapping the mechanical traction forces exerted on the surface by MDCK migration fingers, we show that these structures are mechanical global entities with the leader cells exerting a large traction force. Moreover, the spatial distribution of RhoA differential activity at the basal plane strikingly mirrors this force cartography. We propose that RhoA controls the development of these fingers through mechanical cues: the leader cell drags the structure and the peripheral pluricellular acto-myosin cable prevents the initiation of new leader cells.
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