Journal
NATURE CELL BIOLOGY
Volume 16, Issue 3, Pages 212-214Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2924
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- NCI NIH HHS [R01 CA164746] Funding Source: Medline
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Defective asymmetric cell divisions of stem and progenitor cells are associated with tumorigenesis by a largely unknown mechanism. A signalling axis involving Snail, microRNA-146a and Numb is now shown to regulate the switch between symmetric and asymmetric cell division in colorectal cancer stem cells.
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