Journal
NATURE CELL BIOLOGY
Volume 15, Issue 6, Pages 546-554Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2769
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Funding
- DOD Era of Hope Scholar Award
- NIH New Innovator Award
- Rita Allen Foundation
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Aberrant microRNA (miRNA) expression is a defining feature of human malignancy. Specific miRNAs have been identified as promoters or suppressors of metastatic progression. miRNAs control metastasis through divergent or convergent regulation of metastatic gene pathways. Some miRNA regulatory networks govern cell-autonomous cancer phenotypes, whereas others modulate the cell-extrinsic composition of the metastatic microenvironment. The use of small RNAs as probes into the molecular and cellular underpinnings of metastasis holds promise for the identification of candidate genes for potential therapeutic intervention.
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