Journal
NATURE CELL BIOLOGY
Volume 15, Issue 12, Pages 1387-1397Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2888
Keywords
-
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [MOP-123527]
- Michael Smith Foundation for Health Research (MSFHR)
- Research To Prevent Blindness
- Starr Stem Cell Foundation
- [NIH-EY11307]
- [NIH-EY016805]
Ask authors/readers for more resources
Cilia are present across most eukaryotic phyla and have diverse sensory and motility roles in animal physiology, cell signalling and development. Their biogenesis and maintenance depend on vesicular and intraciliary (intraflagellar) trafficking pathways that share conserved structural and functional modules. The functional units of the interconnected pathways, which include proteins involved in membrane coating as well as small GTPases and their accessory factors, were first experimentally associated with canonical vesicular trafficking. These components are, however, ancient, having been co-opted by the ancestral eukaryote to establish the ciliary organelle, and their study can inform us about ciliary biology in higher organisms.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available