Journal
NATURE CELL BIOLOGY
Volume 15, Issue 4, Pages 338-344Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2717
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Funding
- Dutch Cancer Society [UvA2009-4416, 2012-5612]
- Dutch Science Organization (VICI program)
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Cancer stem cells (CSCs) have been proposed as the driving force of tumorigenesis and the seeds of metastases. However, their existence and role remain a topic of intense debate. Recently, the identification of CSCs in endogenously developing mouse tumours has provided further support for this concept. Here I discuss the challenges in identifying CSCs, their dependency on a supportive niche and their role in metastasis, and propose that stemness is a flexible - rather than fixed - quality of tumour cells that can be lost and gained.
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