Journal
NATURE CELL BIOLOGY
Volume 15, Issue 11, Pages 1351-U210Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2861
Keywords
-
Categories
Funding
- Samuel Waxman Cancer Research Foundation Tumour Dormancy Program [NCI CA109182, CA163131]
- NIEHS [ES017146]
- NYSTEM
- Deutsche Krebshilfe e
- CONICET
- UNQ grants
Ask authors/readers for more resources
In patients, non-proliferative disseminated tumour cells (DTCs) can persist in the bone marrow (BM) while other organs (such as lung) present growing metastasis. This suggested that the BM might be a metastasis 'restrictive soil' by encoding dormancy-inducing cues in DTCs. Here we show in a head and neck squamous cell carcinoma (HNSCC) model that strong and specific transforming growth factor-beta (TGF-beta) signalling in the BM activates the MAPK p38cdp, inducing an (ERK/p38 alpha/beta signalling ratio. This results in induction of DEC2/SHARP1 and p27, downregulation of cyclin-dependent kinase 4 (CDK4) and dormancy of malignant DTCs. TGF-02-induced dormancy required TGF-beta receptor-I (TGF-beta-R1), TGF-beta-RIII and SMAD1/5 activation to induce p27. In lungs, a metastasis 'permissive soil' with low TGF-beta levels, DTC dormancy was short-lived and followed by metastatic growth. Importantly, systemic inhibition of TGF-beta-RI or p38cdp activities awakened dormant DTCs, fuelling multi-organ metastasis. Our work reveals a 'seed and soil' mechanism where TGF-beta and TGF-beta-RII signalling through p38cdp regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available