Journal
NATURE CELL BIOLOGY
Volume 14, Issue 8, Pages 810-U78Publisher
NATURE PORTFOLIO
DOI: 10.1038/ncb2546
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Funding
- NIH [R01GM066258]
- NSF [MCB-0923723]
- China Scholarship Council
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [0923723] Funding Source: National Science Foundation
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Brassinosteroid and gibberellin promote many similar developmental responses in plants; however, their relationship remains unclear. Here we show that BR and GA act interdependently through a direct interaction between the BR-activated BZR1 and GA-inactivated DELLA transcription regulators. GA promotion of cell elongation required BR signalling, where as BR or active BZR1 suppressed the GA-defcient dwarf phenotype. DELLAs directly interacted with BZR1 and inhibited BZR1-DNA binding both in vitro and in vivo. Genome-wide analysis defined a BZR1-dependent GA-regulated transcriptome, which is enriched with light-regulated genes and genes involved in cell wall synthesis and photosynthesis/chloroplast function. GA promotion of hypocotyl elongation requires both BZR1 and the phytochrome-interacting factors (PIFs), as well as their common downstream targets encoding the PRE-family helix-loop-helix factors. The results demonstrate that GA releases DELLA-mediated inhibition of BZR1, and that the DELLA-BZR1-PIF4 interaction defines a core transcription module that mediates coordinated growth regulation by GA, BR and light signals.
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