Journal
NATURE CELL BIOLOGY
Volume 14, Issue 8, Pages 786-788Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2550
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- Telethon [TCR09003] Funding Source: Medline
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Nutrient deprivation and other stress stimuli elicit metabolic changes (such as the induction of autophagy and activation of FOXO transcription factors) that help an organism adapt to stressful conditions. A link between these stress response pathways is revealed by the finding that FOXO3 upregulates the expression of glutamine synthetase to promote glutamine accumulation, inhibit mTOR signalling and promote autophagy.
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