Journal
NATURE CELL BIOLOGY
Volume 14, Issue 1, Pages 2-10Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2403
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Funding
- National Institutes of Health [F32-GM084677, T32-HL07188, F32-GM087900, R01-GM055796]
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Clathrin-mediated endocytosis (CME) is the major pathway for internalization of membrane proteins from the cell surface. Half a century of studies have uncovered tremendous insights into how a clathrin-coated vesicle is formed. More recently, the advent of live-cell imaging has provided a dynamic view of this process. As CME is highly conserved from yeast to humans, budding yeast provides an evolutionary template for this process and has been a valuable system for dissecting the underlying molecular mechanisms. In this review we trace the formation of a clathrin-coated vesicle from initiation to uncoating, focusing on key findings from the yeast system.
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