Journal
NATURE CELL BIOLOGY
Volume 14, Issue 3, Pages 224-230Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2420
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- [GM47434]
- [HD40182]
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In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.
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