Journal
NATURE CELL BIOLOGY
Volume 14, Issue 2, Pages 131-139Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2419
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Funding
- Centre National de la Recherche Scientifique, Institut Pasteur, the National Agency for Research [BLAN-05-0277]
- Fondation pour la Recherche Medicale [DEQ20100318284]
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Cell-fate diversity can be generated by the unequal segregation of the Notch regulator Numb at mitosis in both vertebrates and invertebrates. Whereas the mechanisms underlying unequal inheritance of Numb are understood, how Numb antagonizes Notch has remained unsolved. Live imaging of Notch in sensory organ precursor cells revealed that nuclear Notch is detected at cytokinesis in the daughter cell that does not inherit Numb. Numb and Sanpodo act together to regulate Notch trafficking and establish directional Notch signalling at cytokinesis. We propose that unequal segregation of Numb results in increased endocytosis in one daughter cell, hence asymmetry of Notch at the cytokinetic furrow, directional signalling and binary fate choice.
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