Journal
NATURE CELL BIOLOGY
Volume 14, Issue 7, Pages 656-657Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2534
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The transforming growth factor (TGF-beta) pathway is regulated by ubiquitin-mediated proteolysis at different levels. Two studies now identify deubiquitinating enzymes (DUBs) for the TGF-beta type I receptor. Both ubiquitin-specific peptidase-4 (USP4) and -15 (USP15) extend the life of activated receptors against the negative pressure of receptor-ubiquitinating complexes, but through distinct modes of action.
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