Journal
NATURE CELL BIOLOGY
Volume 14, Issue 11, Pages 1124-1125Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2609
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Funding
- NIGMS NIH HHS [R01 GM057859, T32 GM007092] Funding Source: Medline
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It is well documented that polyploid cells exist in mammalian tissues such as the placenta and liver, but their function and the mechanisms for their formation have remained elusive. Two studies now identify a role for atypical E2F transcription factors in promoting polyploidy in mammals and challenge present theories about the function of polyploidy.
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