Journal
NATURE CELL BIOLOGY
Volume 14, Issue 7, Pages 707-716Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2523
Keywords
-
Categories
Funding
- National Institutes of Health [GM073892]
- Howard Hughes Medical Institute
- [P30 NS047101]
Ask authors/readers for more resources
Although studies on endoplasmic reticulum (ER) structure and dynamics have focused on the ER tubule-forming proteins (reticulons and DP1/Yop1p) and the tubule fusion protein atlastin, nothing is known about the proteins and processes that act to counterbalance this machinery. Here we show that Lnp1p, a member of the conserved Lunapark family, plays a role in ER network formation. Lnp1p binds to the reticulons and Yop1p and resides at ER tubule junctions in both yeast and mammalian cells. In the yeast Saccharomyces cerevisiae, the interaction of Lnp1p with the reticulon protein, Rtn1p, and the localization of Lnp1p to ER junctions are regulated by Sey1p, the yeast orthologue of atlastin. We propose that Lnp1p and Sey1p act antagonistically to balance polygonal network formation. In support of this proposal, we show that the collapsed, densely reticulated ER network in Inp1 Delta cells is partially restored when the GTPase activity of Sey1p is abrogated.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available