Journal
NATURE CELL BIOLOGY
Volume 13, Issue 5, Pages 490-496Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0511-490
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Funding
- Medical Research Council [G0800784, G0800784B] Funding Source: researchfish
- MRC [G0800784] Funding Source: UKRI
- Medical Research Council [G0800784] Funding Source: Medline
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Pluripotency and self-renewal are the hallmarks of embryonic stem cells. This state is maintained by a network of transcription factors and is influenced by specific signalling pathways. Current evidence indicates that multiple pluripotent states can exist in vitro. Here we review the recent advances in studying the transcriptional regulatory networks that define pluripotency, and elaborate on how manipulation of signalling pathways can modulate pluripotent states to varying degrees.
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