Journal
NATURE CELL BIOLOGY
Volume 13, Issue 5, Pages 506-512Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0511-506
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Funding
- Emerald Foundation
- G. Harold and Leila Y. Mathers Charitable Foundation
- ACS
- Calilornia Institute for Regenerative Medicine (CIRM)
- NIH [R01 AG028092, R37 AG23806, R01 AR056849]
- Glenn Foundation for Medical Research
- Department of Veterans Affairs
- Amertical Federation for Aging Research
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Ageing is accompanied by a progressive decline in stem cell function, resulting in less effective tissue homeostasis and repair. Here we discuss emerging invertebrate models that provide insights into molecular pathways of age-related stem cell dysfunction in mammals, and we present various paradigms of how stem cell functionality changes with age, including impaired self-renewal and aberrant differentiation potential.
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