Journal
NATURE CELL BIOLOGY
Volume 13, Issue 5, Pages 616-U275Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2219
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Funding
- National Science Foundation [IOS-1026630, MCB-1004808]
- Biotechnology and Biological Sciences Research Council [BBF02116X1]
- National Institutes of Health [GM47850]
- National High Technology Research and Development Program of China [2009AA101101]
- BBSRC [BB/F02116X/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F02116X/1] Funding Source: researchfish
- Direct For Biological Sciences
- Division Of Integrative Organismal Systems [1026630] Funding Source: National Science Foundation
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0954313] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [1004808] Funding Source: National Science Foundation
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The circadian clock controls many metabolic, developmental and physiological processes in a time-of-day-specific manner in both plants and animals(1,2). The photoreceptors involved in the perception of light and entrainment of the circadian clock have been well characterized in plants(3). However, how light signals are transduced from the photoreceptors to the central circadian oscillator, and how the rhythmic expression pattern of a clock gene is generated and maintained by diurnal light signals remain unclear. Here, we show that in Arabidopsis thaliana, FHY3, FAR1 and HY5, three positive regulators of the phytochrome A signalling pathway, directly bind to the promoter of ELF4, a proposed component of the central oscillator, and activate its expression during the day, whereas the circadian-controlled CCA1 and LHY proteins directly suppress ELF4 expression periodically at dawn through physical interactions with these transcription-promoting factors. Our findings provide evidence that a set of light- and circadian-regulated transcription factors act directly and coordinately at the ELF4 promoter to regulate its cyclic expression, and establish a potential molecular link connecting the environmental light dark cycle to the central oscillator.
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