Journal
NATURE CELL BIOLOGY
Volume 12, Issue 6, Pages 553-562Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb2057
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Funding
- USA-Israel Binational Science Foundation
- Ministero dell'Universita e della Ricerca
- Apulia Region
- University of Bari
- Prinses Beatrix Fonds
- Barth Syndrome Foundation
- National Institutes of Health (NIH)
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T34GM008563, R01GM061721, R01GM059419] Funding Source: NIH RePORTER
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The BH3-only BID (BH3-interacting domain death agonist) protein has a critical function in the death-receptor pathway in the liver by triggering mitochondrial outer membrane permeabilization (MOMP). Here we show that MTCH2/MIMP (mitochondrial carrier homologue 2/Met-induced mitochondrial protein), a novel truncated BID (tBID)-interacting protein, is a surface-exposed outer mitochondrial membrane protein that facilitates the recruitment of tBID to mitochondria. Knockout of MTCH2/MIMP in embryonic stem cells and in mouse embryonic fibroblasts hinders the recruitment of tBID to mitochondria, the activation of Bax/Bak, MOMP, and apoptosis. Moreover, conditional knockout of MTCH2/MIMP in the liver decreases the sensitivity of mice to Fas-induced hepatocellular apoptosis and prevents the recruitment of tBID to liver mitochondria both in vivo and in vitro. In contrast, MTCH2/MIMP deletion had no effect on apoptosis induced by other pro-apoptotic Bcl-2 family members and no detectable effect on the outer membrane lipid composition. These loss-of-function models indicate that MTCH2/MIMP has a critical function in liver apoptosis by regulating the recruitment of tBID to mitochondria.
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