Journal
NATURE CELL BIOLOGY
Volume 12, Issue 9, Pages 823-830Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0910-823
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Funding
- Ministry of Education, Culture, Sports, Science and Technology, Japan
- Toray Science Foundation
- Takeda Science Foundation
- National Institutes of Health [RO1 CA85254, RO1 CA109618, U54 AI057156]
- NATIONAL CANCER INSTITUTE [R01CA109618, R01CA084254] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U54AI057156] Funding Source: NIH RePORTER
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It has been known for many decades that autophagy, a conserved lysosomal degradation pathway, is highly active during differentiation and development. However, until the discovery of the autophagy-related (ATG) genes in the 1990s, the functional significance of this activity was unknown. Initially, genetic knockout studies of ATG genes in lower eukaryotes revealed an essential role for the autophagy pathway in differentiation and development. In recent years, the analyses of systemic and tissue-specific knockout models of ATG genes in mice has led to an explosion of knowledge about the functions of autophagy in mammalian development and differentiation. Here we review the main advances in our understanding of these functions.
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