Journal
NATURE CELL BIOLOGY
Volume 11, Issue 10, Pages 1261-U251Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1971
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Funding
- Telethon Italy Foundation
- Italian Association for Cancer Research (AIRC)
- Deutsche Forschungsgemeinschaft (DFG) [A4, Z2]
- NIH
- NCI
- Center for Cancer Research
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Physiological and premature ageing are characterized by multiple defects in chromatin structure and accumulation of persistent DNA damage. Here we identify the NURD chromatin remodelling complex as a key modulator of these ageing-associated chromatin defects. We demonstrate loss of several NURD components during premature and normal ageing and we find an ageing-associated reduction in HDAC1 activity. Silencing of individual NURD subunits recapitulated chromatin defects associated with ageing and we provide evidence that structural chromatin defects precede DNA damage accumulation. These results outline a molecular mechanism for chromatin defects during ageing.
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