Journal
NATURE CELL BIOLOGY
Volume 11, Issue 4, Pages 451-U198Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1852
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Funding
- National Institutes of Health
- American Heart Association
- Medical Research Council
- Burroughs-Wellcome Fund
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM061010] Funding Source: NIH RePORTER
- Medical Research Council [G0500905] Funding Source: researchfish
- MRC [G0500905] Funding Source: UKRI
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Many cellular structures are assembled from networks of actin filaments, and the architecture of these networks depends on the mechanism by which the filaments are formed. Several classes of proteins are known to assemble new filaments, including the Arp2/3 complex, which creates branched filament networks, and Spire, which creates unbranched filaments(1,2). We find that JMY, a vertebrate protein first identified as a transcriptional co-activator of p53, combines these two nucleating activities by both activating Arp2/3 and assembling filaments directly using a Spire-like mechanism. Increased levels of JMY expression enhance motility, whereas loss of JMY slows cell migration. When slowly migrating HL-60 cells are differentiated into highly motile neutrophil-like cells, JMY moves from the nucleus to the cytoplasm and is concentrated at the leading edge. Thus, JMY represents a new class of multifunctional actin assembly factor whose activity is regulated, at least in part, by sequestration in the nucleus.
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