Journal
NATURE CELL BIOLOGY
Volume 11, Issue 8, Pages 921-923Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0809-921
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senescent cells alter their microenvironment by secreting a growing collection of factors, a phenomenon termed the senescence-associated secretory phenotype (SASP). Cellular senescence is often the result of nuclear DNA damage fuelling a chronic DNA damage response (DDR). Upstream elements of the DDR cascade are necessary for full blown SASP, and additional crosstalk occurs between the DDR and cytokine secretion.
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