Journal
NATURE CELL BIOLOGY
Volume 11, Issue 2, Pages 116-118Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0209-116
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Metazoan cells respond to external stress or infection through multiple signalling pathways that converge on NF-kappa B activation, initiating a program designed to promote survival or trigger cell death. Recent evidence reveals a mechanism for NF-kappa B activation that requires assembly of linear polyubiquitin chains as scaffolds to recruit the activation complex.
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