Journal
NATURE CELL BIOLOGY
Volume 10, Issue 5, Pages 584-592Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1721
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Funding
- MRC [G0501838] Funding Source: UKRI
- Medical Research Council [G0700711B, G0501838] Funding Source: researchfish
- Medical Research Council [G0501838] Funding Source: Medline
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Recent studies have suggested that regeneration of non-haematopoietic cell lineages can occur through heterotypic cell fusion(1-3) with haematopoietic cells of the myeloid lineage(2 - 6). Here we show that lymphocytes also form heterotypic-fusion hybrids with cardiomyocytes, skeletal muscle, hepatocytes and Purkinje neurons. However, through lineage fate-mapping we demonstrate that such in vivo fusion of lymphoid and myeloid blood cells does not occur to an appreciable extent in steady-state adult tissues or during normal development. Rather, fusion of blood cells with different non-haematopoietic cell types is induced by organ-specific injuries or whole-body irradiation(1-10), which has been used in previous studies to condition recipients of bone marrow transplants. Our findings demonstrate that blood cells of the lymphoid and myeloid lineages contribute to various non-haematopoietic tissues by forming rare fusion hybrids, but almost exclusively in response to injuries or inflammation.
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