Journal
NATURE CELL BIOLOGY
Volume 10, Issue 11, Pages 1241-1247Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb1108-1241
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Funding
- Netherlands Organization for Scientific Research (NWO)
- Research Institute Diseases of the Elderly
- SenterNovem IOP-Genomics [IGE03009]
- NIH [1PO1 AG17242-02]
- NIEHS [1UO1 ES011044]
- EC [QRTL-1999-02002]
- Dutch Cancer Society [EUR 99-2004]
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Loss of genome maintenance may causally contribute to ageing, as exemplified by the premature appearance of multiple symptoms of ageing in a growing family of human syndromes and in mice with genetic defects in genome maintenance pathways. Recent evidence revealed a similarity between such prematurely ageing mutants and long-lived mice harbouring mutations in growth signalling pathways. At first sight this seems paradoxical as they represent both extremes of ageing yet show a similar 'survival' response that is capable of delaying age-related pathology and extending lifespan. Understanding the mechanistic basis of this response and its connection with genome maintenance would open exciting possibilities for counteracting cancer or age-related diseases, and for promoting longevity.
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