Journal
NATURE CELL BIOLOGY
Volume 10, Issue 6, Pages 639-641Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0608-639
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store-operated Ca(2+) channels (sOCs) are activated in response to Ca2+ release from the endoplasmic reticulum (ER). The stromal interaction molecule 1 (STIM1) is the ER sensor that transmits the stored Ca2+ content to the pore- forming sOCs Orai and TRPC channels. Recent studies reveal high levels of Orai1 and STIM1 in skeletal muscle, and a prominent role of sOCs in muscle development and function.
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