Journal
NATURE BIOTECHNOLOGY
Volume 31, Issue 3, Pages 230-232Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.2507
Keywords
-
Categories
Funding
- National Research Foundation of Korea [2012-0001225]
- ToolGen, Inc.
- National Research Foundation of Korea [2010-0018267] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
We employ the CRISPR-Cas system of Streptococcus pyogenes as programmable RNA-guided endonucleases (RGENs) to cleave DNA in a targeted manner for genome editing in human cells. We show that complexes of the Cas9 protein and artificial chimeric RNAs efficiently cleave two genomic sites and induce indels with frequencies of up to 33%.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
