Journal
NATURE BIOTECHNOLOGY
Volume 29, Issue 12, Pages 1114-1116Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.2018
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Funding
- National Science Foundation [CCF-0943385, ECCS-0835847]
- MoVeS [FP7-ICT-2009-257005]
- Div Of Electrical, Commun & Cyber Sys
- Directorate For Engineering [835847] Funding Source: National Science Foundation
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We show that difficulties in regulating cellular behavior with synthetic biological circuits may be circumvented using in silico feedback control. By tracking a circuit's output in Saccharomyces cerevisiae in real time, we precisely control its behavior using an in silico feedback algorithm to compute regulatory inputs implemented through a genetically encoded light-responsive module. Moving control functions outside the cell should enable more sophisticated manipulation of cellular processes whenever real-time measurements of cellular variables are possible.
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