Journal
NATURE BIOTECHNOLOGY
Volume 26, Issue 12, Pages 1364-1366Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nbt.1509
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Funding
- Medicen Paris Region
- EC
- ANR
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By analyzing five human embryonic stem (hES) cell lines over long-term culture, we identified a recurrent genomic instability in the human genome. An amplification of 2.5-4.6 Mb at 20q11.21, encompassing similar to 23 genes in common, was detected in four cell lines of different origins. This amplification, which has been associated with oncogenic transformation, may provide a selective advantage to hES cells in culture.
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