Journal
NATURE
Volume 506, Issue 7488, Pages 322-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature12948
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Funding
- Australian National Health and Medical Research Council (NHMRC)
- Victorian State Government through VCA funding of the Victorian Breast Cancer Research Consortium
- Victorian State Government through Operational Infrastructure Support
- Australian Cancer Research Foundation
- Qualtrough Family Bequest
- National Breast Cancer Foundation/Cure Cancer Australia Fellowship
- NHMRC Research Fellowship
- Australia Fellowship
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The mammary epithelium undergoes profound morphogenetic changes during development. Architecturally, it comprises two primary lineages, the inner luminal and outer myoepithelial cell layers. Two opposing concepts on the nature of mammary stem cells (MaSCs) in the postnatal gland have emerged. One model, based on classical transplantation assays, postulates that bipotent MaSCs have a key role in coordinating ductal epithelial expansion and maintenance in the adult gland, whereas the second model proposes that only unipotent MaSCs identified by lineage tracing contribute to these processes. Through clonal cell-fate mapping studies using a stochastic multicolour cre reporter combined with a new three-dimensional imaging strategy, we provide evidence for the existence of bipotent MaSCs as well as distinct long-lived progenitor cells. The cellular dynamics at different developmental stages support a model in which both stem and progenitor cells drive morphogenesis during puberty, whereas bipotent MaSCs coordinate ductal homeostasis and remodelling of the mouse adult gland.
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