Journal
NATURE
Volume 505, Issue 7483, Pages 344-352Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature12986
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Funding
- Leukemia & Lymphoma Society
- US National Institutes of Health [R01 CA-82328]
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Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.
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