Journal
NATURE
Volume 504, Issue 7480, Pages 389-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature12831
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Funding
- IRCM
- Klarman Family Foundation
- NIH [CA087969]
- Villum Kann Rasmussen Foundation
- Dr Miriam and Sheldon G. Adelson Medical Research Foundation
- NCI GAME-ON Cancer Post-GWAS initiative [U19 CA148065-01]
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Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.
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