Journal
NATURE
Volume 502, Issue 7472, Pages 499-506Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature12753
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Funding
- Dutch Scientific Organization (NWO) [714012002, 724012003]
- EU [2010-259743]
- KWF Dutch Cancer Foundation [2009-4459]
- NanoNextNL grant
- Ecole Polytechnique Federale de Lausanne
- University of Geneva
- Swiss National Research Foundation
- ERC
- FP7 program IDEAL
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How a complex animal can arise from a fertilized egg is one of the oldest and most fascinating questions of biology, the answer to which is encoded in the genome. Body shape and organ development, and their integration into a functional organism all depend on the precise expression of genes in space and time. The orchestration of transcription relies mostly on surrounding control sequences such as enhancers, millions of which form complex regulatory landscapes in the non-coding genome. Recent research shows that high-order chromosome structures make an important contribution to enhancer functionality by triggering their physical interactions with target genes.
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