Journal
NATURE
Volume 487, Issue 7405, Pages 51-+Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature11129
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Funding
- Helen Hay Whitney postdoctoral fellowship
- National Institutes of Health (NIH)
- Burroughs Wellcome Fund Career Awards in the Biomedical Sciences
- Engineering and Physical Sciences Research Council [EP/H019472/1]
- McDonnell Center
- National Science Foundation
- Texas Instruments Stanford Graduate Fellowship
- Paul and Daisy Soros Fellowship
- Stanford Medical Scientist Training Program
- NIH [1DP1OD006409]
- NIH NINDS EUREKA [R01-NS066311]
- NIH NINDS BRP [R01-NS064318]
- NIH NINDS CRCNS [R01-NS054283]
- DARPA-DSO REPAIR [N66001-10-C-2010]
- Stanford Center for Integrated Systems
- NSF Center for Neuromorphic Systems Engineering at Caltech
- Office of Naval Research
- Whitaker Foundation
- McKnight Foundation
- Sloan Foundation
- Weston Havens Foundation
- EPSRC [EP/H019472/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/H019472/1] Funding Source: researchfish
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Most theories of motor cortex have assumed that neural activity represents movement parameters. This view derives from what is known about primary visual cortex, where neural activity represents patterns of light. Yet it is unclear how well the analogy between motor and visual cortex holds. Single-neuron responses in motor cortex are complex, and there is marked disagreement regarding which movement parameters are represented. A better analogy might be with other motor systems, where a common principle is rhythmic neural activity. Here we find that motor cortex responses during reaching contain a brief but strong oscillatory component, something quite unexpected for a non-periodic behaviour. Oscillation amplitude and phase followed naturally from the preparatory state, suggesting a mechanistic role for preparatory neural activity. These results demonstrate an unexpected yet surprisingly simple structure in the population response. This underlying structure explains many of the confusing features of individual neural responses.
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