Journal
NATURE
Volume 489, Issue 7415, Pages 250-256Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature11553
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Funding
- NHGRI NIH HHS [U54 HG004968] Funding Source: Medline
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The human body is colonized by a vast array of microbes, which form communities of bacteria, viruses and microbial eukaryotes that are specific to each anatomical environment. Every community must be studied as a whole because many organisms have never been cultured independently, and this poses formidable challenges. The advent of next-generation DNA sequencing has allowed more sophisticated analysis and sampling of these complex systems by culture-independent methods. These methods are revealing differences in community structure between anatomical sites, between individuals, and between healthy and diseased states, and are transforming our view of human biology.
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