Journal
NATURE
Volume 485, Issue 7399, Pages 459-U65Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature11088
Keywords
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Categories
Funding
- Wellcome Trust [083643/Z/07/Z, 093734/Z/10/Z]
- European Research Council (ERC) [281348]
- EMBO
- Medical Research Council Centre for Obesity and Related metabolic Disorders (MRC CORD)
- National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre
- European Commission [018741]
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/C006941/1]
- Engineering and Physical Sciences Research Council (EPSRC) [BB/D019621]
- ENIGMA
- US Department of Energy [DE-AC02-05CH11231]
- National Institutes of Health (NIH) [P50GM076547, R01GM088595, R01GM067152, R21HL102492]
- Netherlands Organisation for Scientific Research (NWO)
- Dutch Science Foundation VICI
- University of Groningen
- Wellcome Trust [083643/Z/07/Z] Funding Source: Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/D019621/1, BB/C006941/1] Funding Source: researchfish
- Medical Research Council [MC_U105170643, MC_UP_1201/4, G0600717B] Funding Source: researchfish
- BBSRC [BB/D019621/1] Funding Source: UKRI
- MRC [MC_UP_1201/4, MC_U105170643] Funding Source: UKRI
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Cellular life emerged similar to 3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth's rotation. The advantage conferred on organisms that anticipate such environmental cycles has driven the evolution of endogenous circadian rhythms that tune internal physiology to external conditions. The molecular phylogeny of mechanisms driving these rhythms has been difficult to dissect because identified clock genes and proteins are not conserved across the domains of life: Bacteria, Archaea and Eukaryota. Here we show that oxidation-reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms. Furthermore, we explore the interconnectivity between these metabolic cycles and transcription-translation feedback loops of the clockwork in each system. Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event similar to 2.5 billion years ago.
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