Journal
NATURE
Volume 491, Issue 7424, Pages 348-356Publisher
NATURE RESEARCH
DOI: 10.1038/nature11704
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Funding
- NIH Diabetes and Digestive and Kidney Diseases Institute [R01DK090625]
- National Institute on Aging [P01AG011412]
- Chicago Biomedical Consortium Searle Funds
- American Diabetes Association [1-09-RA-07]
- Juvenile Diabetes Research Foundation [1-2008-114]
- University of Chicago Diabetes Research and Training Center [P60 DK020595]
- NIH Heart, Lung and Blood Institute [R01HL097817]
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Biological clocks are genetically encoded oscillators that allow organisms to anticipate changes in the light-dark environment that are tied to the rotation of Earth. Clocks enhance fitness and growth in prokaryotes, and they are expressed throughout the central nervous system and peripheral tissues of multicelled organisms in which they influence sleep, arousal, feeding and metabolism. Biological clocks capture the imagination because of their tie to geophysical time, and tools are now in hand to analyse their function in health and disease at the cellular and molecular level.
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