Journal
NATURE
Volume 485, Issue 7397, Pages 185-194Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nature11117
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Funding
- US National Science Foundation [CBET-0932762, CBET-0730312]
- Korea Science and Engineering Foundation
- Ministry of Education, Science and Technology [R32-2008-000-10213-0]
- German Research Foundation [SPP 1170, Bo1864/4-1]
- National Research Foundation of Korea [R32-2012-000-10213-0] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Div Of Chem, Bioeng, Env, & Transp Sys
- Directorate For Engineering [0932762] Funding Source: National Science Foundation
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Over the past ten years, scientific and technological advances have established biocatalysis as a practical and environmentally friendly alternative to traditional metallo- and organocatalysis in chemical synthesis, both in the laboratory and on an industrial scale. Key advances in DNA sequencing and gene synthesis are at the base of tremendous progress in tailoring biocatalysts by protein engineering and design, and the ability to reorganize enzymes into new biosynthetic pathways. To highlight these achievements, here we discuss applications of protein-engineered biocatalysts ranging from commodity chemicals to advanced pharmaceutical intermediates that use enzyme catalysis as a key step.
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